Phasemeter core for intersatellite laser heterodyne interferometry: modelling, simulations and experiments

Inter satellite laser interferometry is a central component of future space-borne gravity instruments like LISA, eLISA, NGO and future geodesy missions. The inherently small laser wavelength allows to measure distance variations with extremely high precision by interfering a reference beam with a measurement beam. The readout of such interferometers is often based on tracking phasemeters, able to measure the phase of an incoming beatnote with high precision over a wide range of frequencies. The implementation of such phasemeters is based on all digital phase-locked loops, hosted in FPGAs. Here we present a precise model of an all digital phase locked loop that allows to design such a readout algorithm and we support our analysis by numerical performance measurements and experiments with analog signals.Comment: 17 pages, 6 figures, accepted for publication in CQ

LISA phasemeter development: Advanced prototyping

We present the status of our investigations on the LISA Phasemeter. The new prototype is based on a custom-designed breadboard with four high-speed ADC and two DAC channels, extended readout capabilities and a large FPGA (field programmable gate array). The required main functionalities and performance of the prototype have been demonstrated in laboratory conditions. © 2009 IOP Publishing Ltd

Towards a gravitational wave observatory designer: sensitivity limits of spaceborne detectors

The most promising concept for low frequency (millihertz to hertz) gravitational wave observatories are laser interferometric detectors in space. It is usually assumed that the noise floor for such a detector is dominated by optical shot noise in the signal readout. For this to be true, a careful balance of mission parameters is crucial to keep all other parasitic disturbances below shot noise. We developed a web application that uses over 30 input parameters and considers many important technical noise sources and noise suppression techniques to derive a realistic position noise budget. It optimizes free parameters automatically and generates a detailed report on all individual noise contributions. Thus one can easily explore the entire parameter space and design a realistic gravitational wave observatory. In this document we describe the different parameters, present all underlying calculations, and compare the final observatory's sensitivity with astrophysical sources of gravitational waves. We use as an example parameters currently assumed to be likely applied to a space mission proposed to be launched in 2034 by the European Space Agency. The web application itself is publicly available on the Internet at http://spacegravity.org/designer. Future versions of the web application will incorporate the frequency dependence of different noise sources and include a more detailed model of the observatory's residual acceleration noise

Caracterización del funcionamiento y la recarga del acuífero del Ventos-Castellar (Alicante)

En el presente trabajo se estudia el funcionamiento hidrodinámico y la recarga del acuífero Ventós-Castellar (Alicante). Se trata de un acuífero desarrollado en calizas, ubicado en el sureste peninsular y del que se aprovechan sus aguas para el abastecimiento de la localidad de Agost. A partir de los datos de evolución piezométrica y mediante la aplicación de un modelo matemático, se pone de manifiesto la gran influencia que ejercen los factores climáticos en estos acuíferos mediterráneos con áreas de recarga de pequeña extensión. Así, ante periodos secos las tasas de recarga pueden llegar a bajar hasta el 1% de la precipitación total. Únicamente los episodios lluviosos de gran intensidad originan recargas significativas en el acuífero. De forma general, se establece que los recursos de estos sistemas son muy escasos, por lo que la existencia de periodos secos se traducen en descensos en los niveles piezométricos que no son fáciles de recuperar a corto y medio plazo. Es por ello que las extracciones de agua en este tipo acuíferos han de realizarse de forma controlada para evitar posteriores problemas que pueden ser interpretados erróneamente como indicios de sobreexplotación.The aim of this work is to study the flow and recharge of the Ventós-Castellar aquifer (Alicante). This is a small karstic aquifer situated in the south-east part of the Iberian Peninsula, whose waters are used to supply the area around the city of Agost. The dynamic of the aquifer is very rapid, indicating a high degree of karstification. A mathematical model based on data of changes in the piezometric level was applied, which highlighted the enormous influence that climatic factors exert in such Mediterranean aquifers having small recharge areas. It indicated that during dry periods the rates of recharge can fall below 1% of the total precipitation. Only high-intensity rainfall events lead to significant recharge in the aquifer. In general terms, we have established that the resources of these systems are very scarce, and that dry periods lead to falls in water levels that are not easily recovered in the short to medium term. For this reason, water pumping from this sort of aquifer must be made in a controlled way in order to avoid subsequent problems, which could be wrongly interpreted as indicating overexploitation.Este trabajo se ha realizado dentro del marco de los proyectos HID97-1047 y REN2000-0529 HID financiados por la CICYT, así como IGCP-488 de la UNESCO y del grupo de investigación GR00-22

Single-element dual-interferometer for precision inertial sensing

Tracking moving masses in several degrees of freedom with high precision and large dynamic range is a central aspect in many current and future gravitational physics experiments. Laser interferometers have been established as one of the tools of choice for such measurement schemes. Using sinusoidal phase modulation homodyne interferometry allows a drastic reduction of the complexity of the optical setup, a key limitation of multi-channel interferometry. By shifting the complexity of the setup to the signal processing stage, these methods enable devices with a size and weight not feasible using conventional techniques. In this paper we present the design of a novel sensor topology based on deep frequency modulation interferometry: the self-referenced single-element dual-interferometer (SEDI) inertial sensor, which takes simplification one step further by accommodating two interferometers in one optic. Using a combination of computer models and analytical methods we show that an inertial sensor with sub-picometer precision for frequencies above 10 mHz, in a package of a few cubic inches, seems feasible with our approach. Moreover we show that by combining two of these devices it is possible to reach sub-picometer precision down to 2 mHz. In combination with the given compactness, this makes the SEDI sensor a promising approach for applications in high precision inertial sensing for both next-generation space-based gravity missions employing drag-free control, and ground-based experiments employing inertial isolation systems with optical readout. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke

Poor prognosis after ischemic stroke or intracerebral hemorrhage is linked to a particular polymorphism in the human gene encoding p53

Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study

Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases, biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these patients. The aim of this study was to evaluate the predictive capacity of biochemical markers of bone turnover for mortality risk, disease progression and SREs in patients with PCa and bone metastases undergoing treatment with zoledronic acid (ZA). Methods: This was an observational, prospective and multicenter study in which ninety-eight patients were included. Patients were treated with ZA (4mg every 4 weeks for 18 months). Data were collected at baseline and 3, 6, 9, 12, 15 and 18 months after the beginning of treatment. Serum levels of bone alkaline phosphtase (BALP), aminoterminal propeptide of procollagen type I (P1NP) and beta-isomer of carboxiterminal telopeptide of collagen I (b-CTX) were analysed at all points in the study. Data on disease progression, SREs development and survival were recorded. Results: Cox regression models with clinical data and bone markers showed that the levels of the three markers studied were predictive of survival time, with b-CTX being especially powerful, in which a lack of normalisation in visit 1 (3 months after the beginning of treatment) showed a 6.3-times more risk for death than in normalised patients. Levels of these markers were also predictive for SREs, although in this case BALP and P1NP proved to be better predictors. We did not find any relationship between bone markers and disease progression. Conclusion: In patients with PCa and bone metastases treated with ZA, b-CTX and P1NP can be considered suitable predictors for mortality risk, while BALP and P1NP are appropriate for SREs. The levels of these biomarkers 3 months after the beginning of treatment are especially importantThis study was supported by Novartis Oncology Spai

Impact of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients: A nationwide study in Spain

Objective To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain. Settings The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden. The effect of these measures on neurosurgical patients, as well as the effect of COVID-19 itself, has not been thoroughly studied. Participants This was a multicentre, nationwide, observational retrospective study of patients who underwent any neurosurgical operation from March to July 2020. Interventions An exploratory factorial analysis was performed to select the most relevant variables of the sample. Primary and secondary outcome measures Univariate and multivariate analyses were performed to identify independent predictors of mortality and postoperative SARS-CoV-2 infection. Results Sixteen hospitals registered 1677 operated patients. The overall mortality was 6.4%, and 2.9% (44 patients) suffered a perioperative SARS-CoV-2 infection. Of those infections, 24 were diagnosed postoperatively. Age (OR 1.05), perioperative SARS-CoV-2 infection (OR 4.7), community COVID-19 incidence (cases/10 5 people/week) (OR 1.006), postoperative neurological worsening (OR 5.9), postoperative need for airway support (OR 5.38), ASA grade =3 (OR 2.5) and preoperative GCS 3-8 (OR 2.82) were independently associated with mortality. For SARS-CoV-2 postoperative infection, screening swab test <72 hours preoperatively (OR 0.76), community COVID-19 incidence (cases/10 5 people/week) (OR 1.011), preoperative cognitive impairment (OR 2.784), postoperative sepsis (OR 3.807) and an absence of postoperative complications (OR 0.188) were independently associated. Conclusions Perioperative SARS-CoV-2 infection in neurosurgical patients was associated with an increase in mortality by almost fivefold. Community COVID-19 incidence (cases/10 5 people/week) was a statistically independent predictor of mortality. Trial registration number CEIM 20/217

A flagship for Austral temperate forest conservation: an action plan for Darwin's frogs brings key stakeholders together

Darwin’s frogs Rhinoderma darwinii and Rhinoderma rufum are the only known species of amphibians in which males brood their offspring in their vocal sacs. We propose these frogs as flagship species for the conservation of the Austral temperate forests of Chile and Argentina. This recommendation forms part of the vision of the Binational Conservation Strategy for Darwin’s Frogs, which was launched in 2018. The strategy is a conservation initiative led by the IUCN SSC Amphibian Specialist Group, which in 2017 convened 30 governmental, non-profit and private organizations from Chile, Argentina and elsewhere. Darwin’s frogs are iconic examples of the global amphibian conservation crisis: R. rufum is categorized as Critically Endangered (Possibly Extinct) on the IUCN Red List, and R. darwinii as Endangered. Here we articulate the conservation planning process that led to the development of the conservation strategy for these species and present its main findings and recommendations. Using an evidence-based approach, the Binational Conservation Strategy for Darwin’s Frogs contains a comprehensive status review of Rhinoderma spp., including critical threat analyses, and proposes 39 prioritized conservation actions. Its goal is that by 2028, key information gaps on Rhinoderma spp. will be filled, the main threats to these species will be reduced, and financial, legal and societal support will have been achieved. The strategy is a multi-disciplinary, transnational endeavour aimed at ensuring the long-term viability of these unique frogs and their particular habitat